Saints defense eyes a marquee Week 2 upset as a hobbled 49ers squad visits New Orleans. With Purdy, Kittle, and Aiyuk sidelined or limited, Spencer Rattler and a rebuilt Saints attack must lean on a stout defense and a smarter game plan to steal a win.

Bold projections color the page: a pass rush that adds five sacks, Rashid Shaheed erupting for big yards, and Cameron Jordan delivering multiple sacks. In a low-scoring, defense-driven game, fantasy managers should chase Saints playmakers while tempering expectations for the visiting offense.

Week 2 fantasy rankings and injury updates drive start/sit decisions in PPR leagues. Christian McCaffrey is cleared for Week 2, while Brock Purdy is out, shifting SF’s offensive plan. Darren Waller is ruled out for the Giants, narrowing Giants’ passing targets. Drake London projects as a low-end WR1 with upside, and Dallas Goedert is sidelined, impacting Eagles’ tight-end run. Top-tier players remain front-and-center: McCaffrey, Gibbs, Bijan Robinson, CeeDee Lamb, Ja’Marr Chase, and Justin Jefferson, with Ridley, Evans, and Walker as reliable mid-to-high-floor options.

Christian McCaffrey is cleared for Week 2, anchoring the top tier, while Bijan Robinson, Jahmyr Gibbs and Saquon Barkley headline the early-season map. Pollard’s workload keeps him in low-end RB2 territory, with Seattle’s backfield trending toward a split between Charbonnet and Walker. Week 2 values hinge on volume, matchup, and pass-game involvement across backfields.

TreVeyon Henderson could see more work in New England, D’Andre Swift needs a TD to reach value, and James Cook returns for Buffalo as backfields normalize. The outlooks emphasize volume, pass-game usage, and injury updates to sharpen start-sit decisions and DFS lines.